Methylene Blue
Supplement Dosage
Methylene blue follows a dose-dependent curve — too little does nothing, too much reverses the benefit. The evidence-based window is 4-30mg per day, and where you start within that range depends on your body weight and experience level. Here is how to dose it correctly.
Three Dosing Tiers
4-5mg/day — Weeks 1-2
Begin at approximately 0.05 mg/kg of body weight. For a 75kg (165 lb) adult, that is roughly 4mg per day. This introductory dose lets you assess tolerance — primarily GI comfort and urine color changes (blue-green urine is normal and expected). Take with food in the morning to avoid potential sleep disruption from the mild stimulatory effect.
12.5mg/day — Maintenance
The standard maintenance dose used across the majority of cognitive and mitochondrial support research. MB Ultra capsules deliver exactly 12.5mg per capsule — one capsule per day, no measuring required. This dose sits comfortably within the therapeutic window and represents the best balance of efficacy and tolerability for most adults.
30mg/day — Upper Limit
Experienced users may titrate up to 30mg/day, but this is the ceiling of the evidence-based window. Beyond this threshold, methylene blue exhibits a biphasic response — it shifts from acting as an antioxidant that supports mitochondrial electron transport to a pro-oxidant that generates reactive oxygen species. More is not better. For a personalized dose calculation, use our interactive dosage calculator.
Why Capsules for Dosing
Liquid drops require measuring each dose with a dropper — and dropper accuracy varies by 10-25% depending on angle, speed, and viscosity. Over a 90-day protocol, that variability compounds into inconsistent dosing that makes it difficult to evaluate whether the supplement is working.
Capsules eliminate that variable entirely. Each MB Ultra capsule contains exactly 12.5mg per capsule of USP-grade methylene blue — same dose, every day, with no measuring. For a detailed breakdown of format trade-offs, see our complete guide to taking methylene blue.
Safety Considerations
- !MAOIs and SSRIs: Never combine methylene blue with monoamine oxidase inhibitors or selective serotonin reuptake inhibitors. Methylene blue inhibits MAO-A, creating serotonin syndrome risk — a potentially life-threatening condition.
- !G6PD Deficiency: Individuals with glucose-6-phosphate dehydrogenase deficiency should avoid methylene blue entirely. It may trigger hemolytic anemia in G6PD-deficient individuals.
- !Body Weight Scaling: Lighter individuals (under 60kg / 132 lb) should start at 3-4mg/day and scale proportionally. The 0.05 mg/kg starting guideline applies across body weights.
Frequently Asked Questions
What is the right methylene blue supplement dosage?+
The evidence-based range for methylene blue supplementation is 4-30mg per day. Beginners should start at 4-5mg/day (approximately 0.05 mg/kg for a 75kg adult) for weeks 1-2 to assess tolerance. The standard maintenance dose is 12.5mg/day — what MB Ultra capsules deliver. Experienced users may titrate up to 30mg/day, but this is the upper limit of the therapeutic window.
Can you take too much methylene blue?+
Yes. Above approximately 30mg/day, methylene blue exhibits a biphasic response — it flips from acting as an antioxidant (supporting mitochondrial function) to a pro-oxidant (generating harmful reactive oxygen species). This is why staying within the 4-30mg/day evidence-based window is critical. Additionally, methylene blue must never be combined with MAOIs or SSRIs due to serotonin syndrome risk, and individuals with G6PD deficiency should avoid it entirely.
Methylene Blue Ultra launches Q3 2026
USP 99.9% purity, 12.5mg capsules, 30ct. Join the waitlist for preferred pricing.