What is the standard methylene blue dose?

The standard starting dose is 0.5-1mg per kg of body weight per day. For most adults, this means 4-8mg/day initially, titrating up to 10-20mg/day over 2-4 weeks. The maximum safe dose is 30mg/day. Individual response varies based on genetics, health status, and goals.

How do I calculate my methylene blue dose by weight?

Multiply your body weight in kilograms by 0.5-1mg. For a 70kg person, the starting range is 35-70mg total, but this is split into daily doses of 4-8mg initially. Beginners should start at the lower end (0.5mg/kg) and titrate up slowly over 2-4 weeks.

Can I take methylene blue with SSRIs?

No. Methylene blue is a potent MAO-A inhibitor and combining it with SSRIs, SNRIs, MAOIs, or other serotonergic medications can cause serotonin syndrome -- a potentially life-threatening condition. Do not use methylene blue while taking these medications without explicit guidance from your prescribing physician.

How long should I wait before increasing my dose?

Wait at least 2 weeks at each dose level before increasing. The standard titration is: Week 1-2 at 50% of target dose, Week 3-4 at full target dose, Week 5+ at maintenance or 125% if tolerated. Slower titration (4 weeks per level) is safer for beginners.

When is the best time to take methylene blue?

Morning (around 8 AM) is optimal. Methylene blue increases alertness and cellular energy, so taking it later in the day may interfere with sleep. If splitting doses, take the second dose by 1 PM -- avoid dosing within 6 hours of bedtime.

Precision Dosing Tool

Methylene Blue Dosage Calculator

Calculate your personalized starting dose and titration schedule based on body weight, experience level, and optimization goals. For a full walkthrough, see our dosing and administration guide.

Use this for methylene blue nootropic dosage mg/kg planning after you have ruled out contraindications and chosen a USP-grade, third-party tested product.

Body Weight70 kg

40kg (88lb)150kg (330lb)

Experience Level

First time using methylene blue

Optimization Goals

Safety Screening Required

Are you currently taking SSRIs, SNRIs, MAOIs, or other serotonergic medications?

Last updated: April 23, 2026Reviewed by: Nick Nicotra, Chief Science Officer

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