Methylene Blue Dosage Calculator & Safety Planner

Start at 5 mg per day, taken in the morning with food, and hold there for at least 7 days. If you are tolerating it, move to 10 mg per day — that is the destination, not a step toward something higher. 20 mg per day is a routine ceiling, and that ceiling is our editorial judgment anchored to the servings actually sold in this category, not a figure from a study. Be clear about what this range is: no published randomized trial has tested chronic daily oral methylene blue in healthy adults for cognitive or mitochondrial endpoints, so this schedule is an extrapolation from single-dose human studies and from chronic dosing in patient populations.

No — not orally. Every human oral study of methylene blue administered a flat fixed dose, not a milligram-per-kilogram dose: Walter-Sack and colleagues (2009) used fixed 500mg oral and 50mg intravenous doses, Rodriguez and colleagues (2016) used a single 280mg oral dose, and Telch and colleagues (2014) used a single 260mg oral dose. The mg/kg figures that circulate online — 0.5-1 mg/kg, 1-2 mg/kg — are intravenous clinical doses given in a hospital, or they come from rodent injection studies. Scaling an oral supplement by body weight invents a precision the evidence does not support. That is why this planner's schedule is flat and why the weight slider on this page does not change your dose.

No. Methylene blue is a potent MAO-A inhibitor (Ki 27 nM), and combining it with SSRIs, SNRIs, MAOIs, tricyclics, triptans, tramadol, linezolid, St John's Wort or MDMA can cause serotonin toxicity, a potentially life-threatening reaction. No dose has been established as safe alongside serotonergic medication — this is categorical, not a matter of taking less. The FDA issued a drug safety communication on this interaction in 2011 and it carries a boxed warning on the prescription product. Do not use methylene blue while taking these medications without explicit guidance from your prescribing physician.

Hold at least 7 days at 5 mg/day before moving up, then at least 14 days at 10 mg/day — at which point you stop increasing. 10 mg/day is the target, not a waypoint on the way to something bigger. There is no bodyweight or "advanced user" exception that raises the 20 mg/day ceiling. If a level feels right, hold there rather than climbing.

Morning, with food. Methylene blue may support alertness and cellular energy, so taking it late in the day may interfere with sleep — avoid dosing within 6 hours of bedtime. Blue-green urine for a day or two after dosing is expected and is not a sign of a problem. Cycling schedules such as 5 days on / 2 days off or 8 weeks on / 2 weeks off are conventions that have grown up around the compound; no trial has tested them.